Article

CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred

2025-05-09

Abstract excerpt

Bacteria can encode dozens of different immune systems that protect them from infection by mobile genetic elements (MGEs). MGEs themselves may also carry immune systems, such as CRISPR-Cas, to target competitor MGEs. It is unclear when this is favoured by natural selection, and whether toxin-antitoxin (TA) systems — common competitive mechanisms carried by plasmids — can alter their efficacy. Here, we develop and...

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Literature Corpus work: 34052553-70f8-5380-82b7-52aba2ae5984
DOI: 10.1101/2025.05.09.653016

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