Article

Tricuspid valve regurgitation accelerates heart failure via a cardio-intestinal innate immune circuit

2026-07-11

Abstract excerpt

Activation of the immune system impacts the progression of heart failure (HF), but the underlying mechanisms remain incompletely understood. Here, we identify a cardio-intestinal innate immune axis that links systemic venous congestion to myocardial inflammation, fibrosis, and functional decline. Using single-cell and single-nucleus transcriptomic profiling in patients and mice with tricuspid regurgitation (TR), w...

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Literature Corpus work: 3a36a6ac-cd29-5ddd-80b4-92b1512d75ea
DOI: 10.64898/2026.07.07.736969

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