Article
Hemodynamic and Metabolic-Inflammatory Phenotyping Across the Cardiac Index Spectrum in Moderate and Severe Tricuspid Regurgitation: Prognostic Implications.
Circulation. Cardiovascular imaging - 1 Apr 2026
Mazzola Matteo, De Biase Nicolò, Giannini Cristina, Sticchi Alessandro, Del Punta Lavinia, Gargani Luna, Mengozzi Alessandro, Virdis Agostino, Armenia Silvia, Cappelli Federica, Duranti Emiliano, Taddei Stefano, Hahn Rebecca, Messika-Zeitoun David, Masi Stefano, De Carlo Marco, Pugliese Nicola Riccardo
Abstract excerpt
BACKGROUND: Moderate and severe tricuspid regurgitation (TR) is associated with poor outcomes, yet current grading systems do not fully capture circulatory heterogeneity. We investigate the relationship of cardiac index (CI) with rest-exercise hemodynamics, metabolic and inflammatory profiles, and clinical outcomes in moderate and severe TR. METHODS: We prospectively enrolled 300 outpatients with atrial...
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