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Article

Wild-type and mutated IDH1/2 enzymes and therapy responses.

Oncogene - 1 Apr 2018

Molenaar Remco J, Maciejewski Jaroslaw P, Wilmink Johanna W, van Noorden Cornelis J F

Abstract excerpt

Isocitrate dehydrogenase 1 and 2 (IDH1/2) are key enzymes in cellular metabolism, epigenetic regulation, redox states, and DNA repair. IDH1/2 mutations are causal in the development and/or progression of various types of cancer due to supraphysiological production of D-2-hydroxyglutarate. In various tumor types, IDH1/2-mutated cancers predict for improved responses to treatment with irradiation or chemotherapy....

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Share to IDH1 gene
Share to Drug Resistance, Neoplasm
Share to Isocitrate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29367755
DOI: 10.1038/s41388-017-0077-z
PMCID: PMC5895605

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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