Article

Cathepsin B Promotes Aβ Proteotoxicity by Modulating Aging Regulating Mechanisms

2023-09-15

Abstract excerpt

<title>Abstract</title> <p>While the activities of certain proteases promote proteostasis and prevent neurodegeneration-associated phenotypes, the protease cathepsin B (CTSB) enhances proteotoxicity in Alzheimer’s disease (AD) model mice, and its levels are elevated in brains of AD patients. How CTSB exacerbates the toxicity of the AD-causing Amyloid β (Aβ), is controversial. Using an activity-based probe, aging-...

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Literature Corpus work: 39ebd39b-19e3-51e4-9bec-3a98ad7f0cfe
DOI: 10.21203/rs.3.rs-3273205/v1

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