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Article

18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures.

Antioxidants & redox signaling - 1 Dec 2016

Papaevgeniou Nikoletta, Sakellari Marianthi, Jha Sweta, Tavernarakis Nektarios, Holmberg Carina I, Gonos Efstathios S, Chondrogianni Niki

Abstract excerpt

AIMS: Proteasomes are constituents of the cellular proteolytic networks that maintain protein homeostasis through regulated proteolysis of normal and abnormal (in any way) proteins. Genetically mediated proteasome activation in multicellular organisms has been shown to promote longevity and to exert protein antiaggregation activity. In this study, we investigate whether compound-mediated proteasome activation is...

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Identifiers

PMID: 26886723
DOI: 10.1089/ars.2015.6494
PMCID: PMC5124744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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