Article

Regulation of Aldosterone Secretion by Substance P and the NK1 Receptor in Aldosterone-Producing Adenomas

2025-06-02

Abstract excerpt

<h4>ABSTRACT</h4> Aldosterone-producing adenoma (APA) is a major cause of primary aldosteronism (PA), the most frequent form of secondary hypertension. Although somatic mutations in ion channels within APA have been shown to activate Ca 2+ signaling and drive aldosterone production, the pathophysiology of PA remains partially understood. Substance P (SP), encoded by the TAC1 gene, is a neuropeptide of the tachy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 39e1a1df-7385-53e2-9f30-2ca7789a408d
DOI: 10.1101/2025.05.28.656733

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regulation of Aldosterone Secretion by Substance P and the NK1 Receptor in Aldosterone-Producing AdenomasDOI 10.1101/2025.05.28.656733Read

ATP1A1 Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation.Semantic proximity Read

Aldosterone-related biochemical phenotypes in adrenal incidentalomas: clinical relevance in a cohort including normotensive patients.Semantic proximity Read

Pharmacology and pathophysiology of mutated KCNJ5 found in adrenal aldosterone-producing adenomas.Semantic proximity Read

Aldosterone-Regulating Receptors and Aldosterone-Driver Somatic Mutations.Semantic proximity Read

The Bioinformatics Analysis of Aldosterone-Producing Adenoma and Verification of Differentially Expressed GenesSemantic proximity Read

Clinical and Steroidogenic Characteristics of Aldosterone-Producing Adenomas With ATPase or CACNA1D Gene Mutations.Semantic proximity Read

Pathogenesis of Adrenal Aldosterone-Producing Adenomas Carrying Mutations of the Na(+)/K(+)-ATPase.Semantic proximity Read

Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma.Semantic proximity Read

PAC1-R null isoform expression in human prostate cancer tissue.Semantic proximity Read

Patients with pheochromocytoma exhibit low aldosterone renin ratio-preliminary reportsSemantic proximity Read

Expression of inflammation-related genes in aldosterone-producing adenomas with KCNJ5 mutation.Semantic proximity Read

A splice variant to PACAP receptor that is involved in spermatogenesis is expressed in astrocytes.Semantic proximity Read