Article
Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma.
Medicine - 1 May 2016
Kishimoto Rui, Oki Kenji, Yoneda Masayasu, Gomez-Sanchez Celso E, Ohno Haruya, Kobuke Kazuhiro, Itcho Kiyotaka, Kohno Nobuoki
Abstract excerpt
We aimed to detect novel genes associated with G protein-coupled receptors (GPCRs) in aldosterone-producing adenoma (APA) and elucidate the mechanisms underlying aldosterone production.Microarray analysis targeting GPCR-associated genes was conducted using APA without known mutations (APA-WT) samples (n = 3) and APA with the KCNJ5 mutation (APA-KCNJ5; n = 3). Since gonadotropin-releasing hormone receptor (GNRHR)...
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