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Article

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer.

Cell - 5 Apr 2018

Lee Suk Hyung, Hu Wenhuo, Matulay Justin T, Silva Mark V, Owczarek Tomasz B, Kim Kwanghee, Chua Chee Wai, Barlow LaMont J, Kandoth Cyriac, Williams Alanna B, Bergren Sarah K, Pietzak Eugene J, Anderson Christopher B, Benson Mitchell C, Coleman Jonathan A, Taylor Barry S, Abate-Shen Cory, McKiernan James M, Al-Ahmadie Hikmat, Solit David B, Shen Michael M

Abstract excerpt

Bladder cancer is the fifth most prevalent cancer in the U.S., yet is understudied, and few laboratory models exist that reflect the biology of the human disease. Here, we describe a biobank of patient-derived organoid lines that recapitulates the histopathological and molecular diversity of human bladder cancer. Organoid lines can be established efficiently from patient biopsies acquired before and after disease...

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Share to Cell Survival
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred NOD

Share to Organoids

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Share to Transplantation, Heterologous

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Source

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Identifiers

PMID: 29625057
DOI: 10.1016/j.cell.2018.03.017
PMCID: PMC5890941

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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