Article

Axonal pathology differentially affects human Purkinje cell subtypes in the essential tremor cerebellum

2025-01-28

Abstract excerpt

The cerebellar cortex is organized into discrete regions populated by molecularly distinct Purkinje cells (PCs), the sole cortical output neurons. While studies in animal models have shown that PC subtypes differ in their vulnerability to disease, our understanding of human PC subtype and vulnerability remains limited. Here, we demonstrate that human cerebellar regions specialized for motor vs cognitive functions...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 395d2b17-ea39-52da-822e-508e1fc74c7b
DOI: 10.1101/2025.01.26.633063

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Axonal pathology differentially affects human Purkinje cell subtypes in the essential tremor cerebellumDOI 10.1101/2025.01.26.633063Read

Genome-Wide Meta-Analysis Identifies 47 Novel Loci and Links Essential Tremor to Ventral Diencephalon and Cerebellum MorphometrySemantic proximity Read

A single-cell eQTL atlas of the human cerebellum reveals vulnerability of oligodendrocytes in essential tremorSemantic proximity Read

<span data-contrast="auto">Essential Tremor: A Focused Literature Review on its Pathophysiology, Neurophysiology, Etiology, and Management<span data-ccp-props="{"201341983":0,"335551550":2,"335551620":2,"335559739":160,"335559740":303}">Semantic proximity Read

A single-cell eQTL atlas of the human cerebellum reveals vulnerability of oligodendrocytes in essential tremorSemantic proximity Read

Single-cell expression QTL analyses of the human cerebellum reveal vulnerability of oligodendrocytes in essential tremor.Semantic proximity Read

Loss of intracerebellar heterogeneity and selective vulnerability in Spinocerebellar ataxia type 1 neurodegenerationSemantic proximity Read

Genotype-associated cerebellar profiles in ALS: focal cerebellar pathology and cerebro-cerebellar connectivity alterations.Semantic proximity Read

A Fully Automated, Atlas-Based Approach for Superior Cerebellar Peduncle Evaluation in Progressive Supranuclear Palsy Phenotypes.Semantic proximity Read

Genome-wide association study of cerebellar volumeSemantic proximity Read

Genome-wide association study of cerebellar volume provides insights into heritable mechanisms underlying brain development and mental health.Semantic proximity Read

Purkinje cell loss in essential tremor: Random sampling quantification and nearest neighbor analysisSemantic proximity Read

FAHN/SPG35: a narrow phenotypic spectrum across disease classifications.Semantic proximity Read