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Article

Single-cell expression QTL analyses of the human cerebellum reveal vulnerability of oligodendrocytes in essential tremor.

Nature genetics - 1 Apr 2026

Castonguay Charles-Etienne, Aboasali Farah, Medeiros Miranda, Alipour Paria, Bornais Kate, Becret Théodore, Schmilovich Zoe, Khayachi Anouar, Rajput Alex, Dion Patrick A, Rouleau Guy A

Abstract excerpt

Essential tremor, a movement disorder characterized by an upper-limb postural and action tremor, is among the most common neurological disorders, affecting 1% of the population worldwide. Despite strong evidence for genetic factors driving the etiology of essential tremor, the underlying pathophysiology remains poorly understood. To understand the effects of genetic risk factors in essential tremor on the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41857318
DOI: 10.1038/s41588-026-02544-8

Genes

BACE2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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