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Article

Genotype-associated cerebellar profiles in ALS: focal cerebellar pathology and cerebro-cerebellar connectivity alterations.

Journal of neurology, neurosurgery, and psychiatry - 1 Nov 2021

Bede Peter, Chipika Rangariroyashe H, Christidi Foteini, Hengeveld Jennifer C, Karavasilis Efstratios, Argyropoulos Georgios D, Lope Jasmin, Li Hi Shing Stacey, Velonakis Georgios, Dupuis Léonie, Doherty Mark A, Vajda Alice, McLaughlin Russell L, Hardiman Orla

Abstract excerpt

OBJECTIVE: Cerebellar disease burden and cerebro-cerebellar connectivity alterations are poorly characterised in amyotrophic lateral sclerosis (ALS) despite the likely contribution of cerebellar pathology to the clinical heterogeneity of the condition. METHODS: A prospective imaging study has been undertaken with 271 participants to systematically evaluate cerebellar grey and white matter alterations, cerebellar...

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Identifiers

PMID: 34168085
DOI: 10.1136/jnnp-2021-326854
PMCID: PMC8522463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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