Article

Structural characterization of a pathogenic antibody underlying vaccine-induced immune thrombotic thrombocytopenia (VITT)

2023-05-29

Abstract excerpt

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but extremely dangerous side effect that has been reported for several adenoviral (Ad)-vectored COVID-19 vaccines. VITT pathology had been linked to production of antibodies that recognize platelet factor 4 (PF4), an endogenous chemokine. In this work we characterize anti-PF4 antibodies obtained from a VITT patient’s blood. Intact-mass MS measurem...

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Literature Corpus work: 1dba3a14-b2d0-557d-9cbc-3f3fd75bd4f0
DOI: 10.1101/2023.05.28.542636

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