Article
Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection.
Nature communications - 20 Aug 2018
Song Peixin, Zheng Nan, Liu Yong, Tian Chen, Wu Xilin, Ma Xiaohua, Chen Deyan, Zou Xue, Wang Guiyang, Wang Huanru, Zhang Yongyang, Lu Sufang, Wu Chao, Wu Zhiwei
Abstract excerpt
Severe Fever with Thrombocytopenia Syndrome (SFTS), an emerging infectious disease caused by a novel phlebovirus, is associated with high fatality. Therapeutic interventions are lacking and disease pathogenesis is yet to be fully elucidated. The anti-viral immune response has been reported, but humoral involvement in viral pathogenesis is poorly understood. Here we show defective serological responses to SFTSV is...
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