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Article

Polyomavirus ALTOs, but not MTs, downregulate viral early gene expression by activating the NF-κB pathway

2024-05-25

Abstract excerpt

Polyomaviruses are small, circular dsDNA viruses that can cause cancer. Alternative splicing of polyomavirus early transcripts generates large and small tumor antigens (LT, ST) that play essential roles in viral replication and tumorigenesis. Some polyomaviruses also express middle tumor antigens (MTs) or A lternate LT O RFs (ALTOs), which are evolutionarily related but have distinct gene structures. MTs are a s...

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Identifiers and source

Literature Corpus work
3954c53a-d8fd-5d80-a9e2-08c1e8b47176
DOI
10.1101/2024.05.24.595774
Open publication

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Polyomavirus ALTOs, but not MTs, downregulate viral early gene expression by activating the NF-κB pathwayDOI 10.1101/2024.05.24.595774
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