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Merkel cell polyomavirus protein ALTO modulates TBK1 activity to support persistent infection

29 Jul 2024

Abstract excerpt

While Merkel cell polyomavirus (MCPyV or MCV) is an abundant virus frequently shed from healthy skin, it is one of the most lethal tumor viruses in immunocompromised individuals, highlighting the crucial role of host immunity in controlling MCPyV oncogenic potential. Despite its prevalence, very little is known about how MCPyV interfaces with the host immune response to maintain asymptomatic persistent infection...

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PMID: 39074144
DOI: 10.1371/journal.ppat.1012170

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