Article

Uridine Metabolism as a Targetable Metabolic Achilles’ Heel for chemo-resistant B-ALL

2025-01-30

Abstract excerpt

Relapse continues to limit survival for patients with B-cell acute lymphoblastic leukemia (B-ALL). Previous studies have independently implicated activation of B-cell developmental signaling pathways and increased glucose consumption with chemo-resistance and relapse risk. Here, we connect these observations, demonstrating that B-ALL cells with active signaling, defined by high expression of phosphorylated ribosom...

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Identifiers and source

Literature Corpus work: 39021128-8c0c-5ed1-8507-58e1c930ebf0
DOI: 10.1101/2025.01.27.635108

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