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Article

Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice.

PloS one - 1 Jan 2012

Frock Richard L, Chen Steven C, Da Dao-Fu, Frett Ellie, Lau Carmen, Brown Christina, Pak Diana N, Wang Yuexia, Muchir Antoine, Worman Howard J, Santana Luis F, Ladiges Warren C, Rabinovitch Peter S, Kennedy Brian K

Abstract excerpt

Lmna(-/-) mice display multiple tissue defects and die by 6-8 weeks of age reportedly from dilated cardiomyopathy with associated conduction defects. We sought to determine whether restoration of lamin A in cardiomyocytes improves cardiac function and extends the survival of Lmna(-/-) mice. We observed increased total desmin protein levels and disorganization of the cytoplasmic desmin network in ~20% of Lmna(-/-)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22905185
DOI: 10.1371/journal.pone.0042918
PMCID: PMC3419749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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