Article

Lysyl oxidase promotes neuronal ferroptosis exacerbating seizure-induced hippocampal damage

2019-11-12

Abstract excerpt

Epilepsy is a serious neurological disorder and characterized by recurrent and unprovoked seizures. A critical pathological factor in the seizure genesis is neuronal loss. However, mechanisms which lead to neuronal death remain elusive. Our present investigation depicted that ferroptosis, a recently discovered iron- and lipid peroxidation-dependent cell death, probably served as a mechanism in murine models of kai...

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Literature Corpus work: 38f9e2ed-239e-52be-a5fa-c71f36ce6f38
DOI: 10.1101/839852

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