LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis

Abstract excerpt

Ferroptosis has emerged as a new programmed cell death modality highly relevant to disease. 1 Ferroptosis was initially discovered as an iron-dependent non-apoptotic cell death induced by a serial of ferroptosis-inducing agents (FIN), such as erastin and RSL3. Erastin activates ferroptosis by inhibiting the activity of system Xc − , a cystine-glutamate antiporter, resulting in the depletion of cellular cysteine...

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