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Article

Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production.

Neurobiology of aging - 1 Jan 2012

Wu Zhihao, Du Yumei, Xue Hua, Wu Yongsheng, Zhou Bing

Abstract excerpt

The neurotoxicity of aluminum (Al) - the most abundant metal element on earth - has been known for years. However, the mechanism of Al-induced neurodegeneration and its relationship to Alzheimer's disease are still controversial. In particular, in vivo functional data are lacking. In a Drosophila model with chronic dietary Al overloading, general neurodegeneration and several behavioral changes were observed....

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Source

Identifiers

PMID: 20674094
DOI: 10.1016/j.neurobiolaging.2010.06.018

Genes

SOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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