Article

Partitioning the genetic architecture of amyotrophic lateral sclerosis

2018-12-23

Abstract excerpt

The genetic basis of sporadic amyotrophic lateral sclerosis (ALS) is not well understood. Using large genome-wide association studies and validated tools to quantify genetic overlap, we systematically identified single nucleotide polymorphisms (SNPs) associated with ALS conditional on genetic data from 65 different traits and diseases from >3 million people. We found strong genetic enrichment between ALS and a num...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df589246-899d-5bb3-8803-66ddef560c59
DOI: 10.1101/505693

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Partitioning the genetic architecture of amyotrophic lateral sclerosisDOI 10.1101/505693Read

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.Semantic proximity Read

Genetics of Amyotrophic Lateral SclerosisSemantic proximity Read

Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types.Semantic proximity Read

Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell typesSemantic proximity Read

Causal Inference of Genetic Variants and Genes in Amyotrophic Lateral SclerosisSemantic proximity Read

Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis.Semantic proximity Read

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biologySemantic proximity Read

Genome-Wide Gene-Set Analysis Identifies Molecular Mechanisms Associated with ALS.Semantic proximity Read

Characterising the Genetic Landscape of Amyotrophic Lateral Sclerosis: A Catalogue and Assessment of Over 1,000 Published Genetic VariantsSemantic proximity Read

Molecular Taxonomy of Sporadic Amyotrophic Lateral Sclerosis Using Disease-Associated GenesSemantic proximity Read

Gene co-expression network analysis in human spinal cord highlights mechanisms underlying amyotrophic lateral sclerosis susceptibility.Semantic proximity Read

Genome-wide analyses reveal shared and distinct genetic architecture linking amyotrophic lateral sclerosis, sporadic frontotemporal dementia and cognitive traitsSemantic proximity Read