An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1α

Abstract excerpt

<title>Abstract</title> <p>Accumulating studies have shown that E3 ligases play crucial roles in regulating cellular biological processes and signaling pathways during carcinogenesis via ubiquitination. Tripartite-motif (TRIM) ubiquitin E3 ligases consist of over 70 members. However, the clinical significance and their contributions to tumorigenesis remain largely unknown. In this study, we analyzed the RNA-seque...

Topics

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• Autophagy in Disease and Therapy
• Cancer Mechanisms and Therapy
• Cancer-related Molecular Pathways
• Cytokine Signaling Pathways and Interactions
• interferon and immune responses
• MicroRNA in disease regulation
• Peptidase Inhibition and Analysis
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

38b1571c-1e67-5d8b-9e6f-ca5b45a9e9f2

DOI

10.21203/rs.3.rs-3493586/v1