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Tripartite motif-containing protein 26 promotes colorectal cancer growth by inactivating p53

24 Feb 2025

Abstract excerpt

Tripartite motif-containing protein 26 (TRIM26) is an E3 ubiquitin ligase that exhibits divergent roles in various cancer types (oncogenic and anti-oncogenic). This study investigates the interaction of TRIM26 with the tumor suppressor protein p53 in colorectal cancer (CRC) cells by performing a comprehensive set of biochemical, cell-based assays, and xenograft experiments. As a result, we found that...

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PMID: 39994352
DOI: 10.1038/s41418-025-01463-1

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