The dual role of TRIM3 in colorectal cancer dependent on p53 status by retaining p53 in the cytoplasm to decrease its expression in the nuclei

Abstract excerpt

<title>Abstract</title> <p>Colorectal cancer is a very heterogeneous disease caused by the interaction of genetic and environmental factors. P53, a few exceptions, is a frequent mutation and plays a critical role in the adenoma-carcinoma transition during the tumorous pathological process. Our team screened the series of genes’ expression by high-content screening techniques to discover TRIM3 a newly tumor-associ...

Topics

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• Cancer Mechanisms and Therapy
• Cancer-related Molecular Pathways
• Cell death mechanisms and regulation
• Cytokine Signaling Pathways and Interactions
• Genomics and Phylogenetic Studies
• interferon and immune responses
• Peptidase Inhibition and Analysis
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

21566184-6b6a-558d-8b1f-79bf25b529f7

DOI

10.21203/rs.3.rs-1983354/v1