Article
NF-kappaB and epithelial to mesenchymal transition of cancer.
Journal of cellular biochemistry - 1 Jun 2008
Min Chengyin, Eddy Sean F, Sherr David H, Sonenshein Gail E
Abstract excerpt
During progression of an in situ to an invasive cancer, epithelial cells lose expression of proteins that promote cell-cell contact, and acquire mesenchymal markers, which promote cell migration and invasion. These events bear extensive similarities to the process of epithelial to mesenchymal transition (EMT), which has been recognized for several decades as critical feature of embryogenesis. The NF-kappaB family...
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