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Computational and Experimental Identification of Potential Neutralizing Peptides Derived from Human ACE2 Against SARS-CoV-2 Infection

2025-09-02

Abstract excerpt

<h4>ABSTRACT</h4> The human angiotensin-converting enzyme 2 (hACE2) is the primary receptor for the entry of SARS-CoV-2. Some human alleles of ACE2 exhibit an improved affinity for the SARS-CoV-2 Spike protein. However, the impact of ACE2 polymorphisms on SARS-CoV-2 infection remains unclear. Our previous study predicted that G431 and S514 in the receptor-binding domain (RBD) od SARS-CoV-2 S1 domain are important...

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Literature Corpus work: db4e64a0-702b-5904-9741-68585c557782
DOI: 10.1101/2025.09.01.673483

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