Article

Development of a Hemoglobin Beta Chain Gene Knockout Syrian Hamster Model for β-Thalassemia and Oxidative Stress

2025-05-08

Abstract excerpt

<h4>Background: </h4> /Objectives: Notable similarities in lipid metabolism exist between human and golden Syrian hamster relative to most other rodents. A model for β-thalassemia in hamster was sought via knocking out the hemoglobin β-chain (HBB) gene. There are two HBB genes, as well as seven β-like alleles, predicted in the hamster genome, yet none have been functionally characterized. <h4>Methods:</h4> To deve...

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Literature Corpus work: 385c712a-fc35-5e00-a141-a1724b1ed724
DOI: 10.20944/preprints202505.0593.v1

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