Article
A synthetic model of human beta-thalassemia erythropoiesis using CD34+ cells from healthy adult donors.
PloS one - 1 Jan 2013
Lee Y Terry, Kim Ki Soon, Byrnes Colleen, de Vasconcellos Jaira F, Noh Seung-Jae, Rabel Antoinette, Meier Emily R, Miller Jeffery L
Abstract excerpt
Based upon the lack of clinical samples available for research in many laboratories worldwide, a significant gap exists between basic and clinical studies of beta-thalassemia major. To bridge this gap, we developed an artificially engineered model for human beta thalassemia by knocking down beta-globin gene and protein expression in cultured CD34+ cells obtained from healthy adults. Lentiviral-mediated...
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