A Disease-causing Human Osteoprotegerin Mutant Exists in Hyper-oligomerized Forms

Abstract excerpt

Recently, a human mutation of OPG was identified to be associated with familial forms of osteoarthritis. This missense mutation (c.1205A=>T; p.Stop402Leu) occurs on the stop codon of OPG, which results in a 19-residue appendage to the C-terminus (OPG +19 ). The biochemical consequence of this unusual sequence alteration remains unknown. Here we expressed OPG +19 in 293 cells and the mutant OPG was purified to homo...

Topics

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• Biomarkers
• Bone Diseases
• Mutation
• Osteitis Deformans
• Osteoclasts
• Osteoprotegerin
• RANK Ligand
• Receptor Activator of Nuclear Factor-kappa B

Identifiers and source

Literature Corpus work

384a26f8-cbad-550e-9318-2146d74544ee

DOI

10.21203/rs.3.rs-1273500/v1