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Article

Sequence variations in the osteoprotegerin gene promoter in patients with postmenopausal osteoporosis.

The Journal of clinical endocrinology and metabolism - 1 Sept 2002

Arko B, Prezelj J, Komel R, Kocijancic A, Hudler P, Marc J

Abstract excerpt

Osteoprotegerin (OPG) is a recently discovered member of the TNF receptor superfamily that acts as an important paracrine regulator of bone remodeling. OPG knockout mice develop severe osteoporosis, whereas administration of OPG can prevent ovariectomy-induced bone loss. These findings implicate a role for OPG in the development of osteoporosis. In the present study, we screened the OPG gene promoter for sequence...

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Source

Identifiers

PMID: 12213850
DOI: 10.1210/jc.2002-020124

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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