Article
Common Variants of the OPG gene Are Associated with Osteoporosis Risk: A Meta-Analysis.
Genetic testing and molecular biomarkers - 1 Sept 2021
Li Xiaobin, Cheng Junwen, Dong Bin, Yu Xiaoping, Zhao Xiaona, Zhou Zhikang
Abstract excerpt
Background: The RANKL/RANK/OPG signaling pathway plays a critical role in osteoclastogenesis and bone remodeling. The associations between sequence variants of the osteoprotegerin (OPG) gene and osteoporosis risk have been widely investigated but remain inconclusive. Objective: We performed a meta-analysis to evaluate the associations between OPG gene variants and osteoporosis risk. Methods: We searched...
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