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Article

[Role of OPG in regulation of bone remodeling].

Clinical calcium - 1 Sept 2006

Nakamichi Yuko, Udagawa Nobuyuki

Abstract excerpt

Osteoprotegerine (OPG) acts as a decoy receptor for receptor activator of NF-kappaB (RANK) ligand (RANKL) to compete against RANK. OPG-deficient mice exhibit severe osteoporosis with accelerated bone remodeling. In human, several homozygous mutations in OPG gene were found in patients with juvenile Paget's disease. Missense mutations in cysteine residues in ligand binding domain, as well as complete deletion...

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Source

Identifiers

PMID: 16951469
DOI: CliCa060914631468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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[Role of OPG in regulation of bone remodeling].PMID 16951469Read ↗

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RANKL/OPG; Critical role in bone physiology.Semantic proximity Read ↗

Biology of the RANKLâ€“RANKâ€“OPG System in Immunity, Bone, and BeyondSemantic proximity Read ↗

Function of OPG as a traffic regulator for RANKL is crucial for controlled osteoclastogenesisSemantic proximity Read ↗

[OPG(osteoprotegerin)/OCIF(osteoclastogenesis inhibitory factor)].Semantic proximity Read ↗

Osteoprotegerin (OPG)/RANK-L system in juvenile idiopathic arthritis: is there a potential modulating role for OPG/RANK-L in bone injury?Semantic proximity Read ↗

Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin.Semantic proximity Read ↗

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