[Genomic approaches to bone and joint diseases. Mutations of RANK, OPG and RANKL genes found in humans].

Abstract excerpt

Molecular mechanisms of osteoclast formation and activation have been clarified since the discovery of osteoprotegerin (OPG). When receptor activator of NF-kappaB ligands (RANKL) and macrophage colony stimulating factors (M-CSF) bind their receptors RANK and c-fms, respectively, osteoclast precursor cells differentiate into osteoclasts. OPG interferes with the interactions between RANK and RANKL, and inhibits...

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