Article
Genetic association and altered gene expression of osteoprotegerin in otosclerosis patients.
Annals of human genetics - 1 Jul 2015
Priyadarshi Saurabh, Ray Chinmay Sundar, Biswal Narayan Chandra, Nayak Soumya Ranjan, Panda Khirod Chandra, Desai Ashim, Ramchander Puppala Venkat
Abstract excerpt
Otosclerosis (OTSC) is a late-onset hearing disorder characterized by increased bone turnover in the otic capsule. Disturbed osteoprotegerin expression has been found in the otosclerotic foci which may have an important role in the pathogenesis of OTSC. To identify the genetic risk factors, we sequenced the coding region and exon-intron boundaries of the OPG gene in 254 OTSC patients and 262 controls. Sequence...
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