Article

NRas Nanoclusters Mediate Crosstalk Between BRAF/ERK and PI3K/AKT Signalling in Melanoma Cells

2025-09-26

Abstract excerpt

Melanocyte signaling through the MAPK pathway is orchestrated by NRas and relayed downstream via multiple effectors, such as RAF, Ral, and PI3K. In spite of their significance, the molecular mechanisms of signaling relay by NRas, their dynamics and potential as therapeutic targets remain unclear. Using multi-color single molecule localization microscopy (PALM and dSTORM), we resolved the mutual nanoscale organizat...

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Literature Corpus work: 383f71d3-486b-5e37-8eb3-88429b2b7f5a
DOI: 10.20944/preprints202509.1386.v1

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