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The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency

2020-11-27

Abstract excerpt

Human pluripotent stem cells (PSCs) express human endogenous retrovirus type-H (HERV-H), which exists as more than a thousand copies on the human genome and frequently produces chimeric transcripts as long-non-coding RNAs (lncRNAs) fused with downstream neighbor genes. Previous studies showed that HERV-H expression is required for the maintenance of PSC identity, and aberrant HERV-H expression attenuates neural di...

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Identifiers and source

Literature Corpus work
3835ec1a-aeba-587e-920f-2ccf57612d07
DOI
10.1101/2020.11.25.397935
Open publication

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The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotencyDOI 10.1101/2020.11.25.397935
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