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Article

Hippocampal Transcriptome Profile of Persistent Memory Rescue in a Mouse Model of THRA1 Mutation-Mediated Resistance to Thyroid Hormone.

Scientific reports - 8 Jan 2016

Wang Yiqiao, Fisahn André, Sinha Indranil, Nguyen Dinh Phong, Sterzenbach Ulrich, Lallemend Francois, Hadjab Saїda

Abstract excerpt

Hypothyroidism due to THRA1 (gene coding for thyroid hormone receptor α1) mutation-mediated Resistance to Thyroid Hormone (RTH) has been recently reported in human and is associated with memory deficits similar to those found in a mouse model for Thra1 mutation mediated RTH (Thra1(+/m) mice). Here, we show that a short-term treatment of Thra1(+/m) mice with GABAA receptor antagonist pentylenetetrazol (PTZ)...

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Identifiers

PMID: 26743578
DOI: 10.1038/srep18617
PMCID: PMC4705459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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