Article

Altered muscle niche contributes to myogenic deficit in the D2- <i>mdx</i> model of severe DMD

2023-03-28

Abstract excerpt

Lack of dystrophin is the genetic basis for the Duchenne muscular dystrophy (DMD). However, disease severity varies between patients, based on specific genetic modifiers. D2- mdx is a model for severe DMD that exhibits exacerbated muscle degeneration and failure to regenerate even in the juvenile stage of the disease. We show that poor regeneration of juvenile D2- mdx muscles is associated with enhanced inflamma...

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Literature Corpus work: 37f713d4-eb5d-5aca-9604-df137d02bbb9
DOI: 10.1101/2023.03.27.534413

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Altered muscle niche contributes to myogenic deficit in the D2- <i>mdx</i> model of severe DMDDOI 10.1101/2023.03.27.534413Read

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