Back to search

Article

iPSC-derived skeletal muscle spheroids for Duchenne Muscular Dystrophy modeling

2025-06-05

Abstract excerpt

<h4>Background</h4> The progressive skeletal muscle degeneration observed in Duchenne Muscular Dystrophy (DMD) patients requires multiple cycles of satellite cells (SCs) activation to promote tissue regeneration. Dystrophic SCs present intrinsic defects, and the disrupting fibrotic niche hinders appropriate muscle recovery. Traditional 2D culture systems face challenges in modeling the DMD muscle niche and SCs be...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
cc7a0ca9-ff23-53d9-b6d7-b1d034ccd0b9
DOI
10.1101/2025.06.05.657880
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
iPSC-derived skeletal muscle spheroids for Duchenne Muscular Dystrophy modelingDOI 10.1101/2025.06.05.657880
Generation of Skeletal Muscle Organoids from Human Pluripotent Stem CellsSemantic proximity
Myogenesis modelled by human pluripotent stem cells uncovers Duchenne muscular dystrophy phenotypes prior to skeletal muscle commitmentSemantic proximity
Generation of Skeletal Muscle Organoids from Human Pluripotent Stem Cells to Model Myogenesis and Muscle RegenerationSemantic proximity
Human induced pluripotent stem cell models for the study and treatment of Duchenne and Becker muscular dystrophiesSemantic proximity
Myogenic Differentiation of Muscular Dystrophy-Specific Induced Pluripotent Stem Cells for Use in Drug DiscoverySemantic proximity
Generation of skeletal muscle cells from embryonic and induced pluripotent stem cells as an <i>in vitro</i> model and for therapy of muscular dystrophiesSemantic proximity
Myogenesis modelled by human pluripotent stem cells: a multi‐omic study of Duchenne myopathy early onsetSemantic proximity
Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modelingSemantic proximity
A Human Pluripotent Stem Cell Model of Facioscapulohumeral Muscular Dystrophy-Affected Skeletal MusclesSemantic proximity
3D human induced pluripotent stem cell–derived bioengineered skeletal muscles for tissue, disease and therapy modelingSemantic proximity
Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model.Semantic proximity
Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue EngineeringSemantic proximity
Select a neighboring publication to make it the new centre.