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Article

Combinatorial activation of the WNT‐dependent fibrogenic program by distinct complement subunits in dystrophic muscle

6 Nov 2023

Abstract excerpt

Fibrosis is associated with compromised muscle functionality in Duchenne muscular dystrophy (DMD). We report observations with tissues from dystrophic patients and mice supporting a model to explain fibrosis in DMD, which relies on the crosstalk between the complement and the WNT signaling pathways and the functional interactions of two cellular types. Fibro-adipogenic progenitors and macrophages, which populate...

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PMID: 37927228
DOI: 10.15252/emmm.202317405

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