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Prednisolone rescues Duchenne Muscular Dystrophy phenotypes in human pluripotent stem cells-derived skeletal muscle <i>in vitro</i>

2020-10-29

Abstract excerpt

Duchenne Muscular Dystrophy (DMD) is a devastating genetic disease leading to degeneration of skeletal muscles and premature death. How dystrophin absence leads to muscle wasting remains unclear. Here, we describe an optimized protocol to differentiate human induced Pluripotent Stem Cells (iPSC) to a late myogenic stage. This allows to recapitulate classical DMD phenotypes (mislocalization of proteins of the Dystr...

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Literature Corpus work
e44ec154-179b-583a-87db-ec576a66b8b9
DOI
10.1101/2020.10.29.360826
Open publication

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Prednisolone rescues Duchenne Muscular Dystrophy phenotypes in human pluripotent stem cells-derived skeletal muscle <i>in vitro</i>DOI 10.1101/2020.10.29.360826
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