Article

Early mitochondrial stress and metabolic imbalance lead to photoreceptor cell death in retinal degeneration

2021-10-10

Abstract excerpt

<h4>ABSTRACT</h4> Neurodegenerative diseases exhibit extensive genetic heterogeneity and complex etiology with varying onset and severity. To deduce the mechanism leading to retinal degeneration, we adopted a temporal multi-omics approach and examined molecular and cellular events before the onset of photoreceptor cell death in the widely-used Pde6b rd1/rd1 ( rd1 ) mouse model. Transcriptome profiling of neona...

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Literature Corpus work: 99d112f7-730c-55d3-b7b2-f9e75bc9e60d
DOI: 10.1101/2021.10.10.463827

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