Article

Impaired yolk sac NAD metabolism disrupts murine embryogenesis with relevance to human birth defects

2024-05-08

Abstract excerpt

Congenital malformations can originate from numerous genetic or non-genetic factors but in most cases the causes are unknown. Genetic disruption of nicotinamide adenine dinucleotide (NAD) de novo synthesis causes multiple malformations, collectively termed Congenital NAD Deficiency Disorder (CNDD), highlighting the necessity of this pathway during embryogenesis. Previous work in mice shows that NAD deficiency per...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e4faac9a-6caa-5814-9ecf-ebc267691c91
DOI: 10.1101/2024.05.07.592899

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impaired yolk sac NAD metabolism disrupts murine embryogenesis with relevance to human birth defectsDOI 10.1101/2024.05.07.592899Read

Nicotinamide Adenine Dinucleotide Deficiency and Its Impact on Mammalian Development.Semantic proximity Read

A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder.Semantic proximity Read

Bi-allelic Mutations in NADSYN1 Cause Multiple Organ Defects and Expand the Genotypic Spectrum of Congenital NAD Deficiency Disorders.Semantic proximity Read

Metabolism and Congenital Malformations - NAD's Effects on Development.Semantic proximity Read

Maternal heterozygosity of Slc6a19 causes metabolic perturbation and congenital NAD deficiency disorder in miceSemantic proximity Read

Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryosSemantic proximity Read

Nuclear NAD <sup>+</sup> -biosynthetic enzyme NMNAT1 facilitates survival of developing retinal neuronsSemantic proximity Read

A zebrafish model of nicotinamide adenine dinucleotide (NAD <sup>+</sup> ) deficiency-derived congenital disordersSemantic proximity Read

New cases that expand the genotypic and phenotypic spectrum of Congenital NAD Deficiency Disorder.Semantic proximity Read

Disruptive NADSYN1 Variants Implicated in Congenital Vertebral Malformations.Semantic proximity Read

NAD Deficiency, Congenital Malformations, and Niacin Supplementation.Semantic proximity Read

Clinical heterogeneity of NADSYN1 ‐associated VCRL syndromeSemantic proximity Read