Article

Prevalence and mutational determinants of high tumor mutation burden in breast cancer

2019-08-24

Abstract excerpt

<h4>Background</h4> High tumor mutation burden (TMB) has been associated with benefit to immunotherapy in multiple tumor types. However, the prevalence of hypermutated breast cancer is not well described. The aim of this study is to evaluate frequency, mutational patterns, and genomic profile of hypermutated breast cancer. <h4>Patients and Methods</h4> We used de-identified data from individuals with primary or...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 37ceecee-f534-5a81-9b2e-3282c34c5ff6
DOI: 10.1101/745265

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Prevalence and mutational determinants of high tumor mutation burden in breast cancerDOI 10.1101/745265Read

Prevalence and mutational determinants of high tumor mutation burden in breast cancer.Semantic proximity Read

Prevalence and molecular features of TMB-high and MSI-high breast cancer assessed by gene panel testingSemantic proximity Read

High Tumor Mutation Burden and Other Immunotherapy Response Predictors in Breast Cancers: Associations and Therapeutic Opportunities.Semantic proximity Read

The Influence of Cancer Molecular Subtypes and Treatment on the Mutation Spectrum in Metastatic Breast Cancers.Semantic proximity Read

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes.Semantic proximity Read

Targeted sequencing reveals the somatic mutation landscape in a Swedish breast cancer cohort.Semantic proximity Read

The landscape of cancer genes and mutational processes in breast cancer.Semantic proximity Read

The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequenciesSemantic proximity Read

Nonamplification ERBB2 genomic alterations in 5605 cases of recurrent and metastatic breast cancer: An emerging opportunity for anti-HER2 targeted therapies.Semantic proximity Read

APOBEC3 mutagenesis drives therapy resistance in breast cancerSemantic proximity Read

Clinical and molecular relevance of mutant-allele tumor heterogeneity in breast cancer.Semantic proximity Read

High tumor mutation burden is associated with DNA damage repair gene mutation in breast carcinomas.Semantic proximity Read