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Article

Prevalence and mutational determinants of high tumor mutation burden in breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Mar 2020

Barroso-Sousa R, Jain E, Cohen O, Kim D, Buendia-Buendia J, Winer E, Lin N, Tolaney S M, Wagle N

Abstract excerpt

BACKGROUND: High tumor mutation burden (TMB) can benefit immunotherapy for multiple tumor types, but the prevalence of hypermutated breast cancer is not well described. The aim of this study was to evaluate the frequency, mutational patterns, and genomic profile of hypermutated breast cancer. PATIENTS AND METHODS: We used de-identified data from individuals with primary or metastatic breast cancer from six...

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PMID: 32067680
DOI: 10.1016/j.annonc.2019.11.010

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