Article

Learning Gene Networks Underlying Clinical Phenotypes Using SNP Perturbations

2018-09-10

Abstract excerpt

Recent technologies are generating an abundance of genome sequence data and molecular and clinical phenotype data, providing an opportunity to understand the genetic architecture and molecular mechanisms underlying diseases. Previous approaches have largely focused on the co-localization of single-nucleotide polymorphisms (SNPs) associated with clinical and expression traits, each identified from genome-wide assoc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3759d8fd-5070-5933-b73c-db8d6c0fc503
DOI: 10.1101/412817

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Learning Gene Networks Underlying Clinical Phenotypes Using SNP PerturbationsDOI 10.1101/412817Read

Learning gene networks underlying clinical phenotypes using SNP perturbation.Semantic proximity Read

Learning gene networks under SNP perturbations using eQTL datasets.Semantic proximity Read

Learning gene networks under SNP perturbation using SNP and allele-specific expression dataSemantic proximity Read

Phenotype prediction by integrative network analysis of SNP and gene expression microarrays.Semantic proximity Read

Causal modeling of gene effects from regulators to programs to traits: integration of genetic associations and Perturb-seqSemantic proximity Read

Gene-Gene Interaction Detection with Deep LearningSemantic proximity Read

Inference of SNP-gene regulatory networks by integrating gene expressions and genetic perturbations.Semantic proximity Read

Gene-gene interaction detection with deep learning.Semantic proximity Read

Gene regulatory network structure informs the distribution of perturbation effectsSemantic proximity Read

Learning Genetic Perturbation Effects with Variational Causal InferenceSemantic proximity Read

Causal modelling of gene effects from regulators to programs to traits.Semantic proximity Read

Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanismsSemantic proximity Read