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A spatially-resolved human brain proteome atlas for understanding function and disease

2025-10-16

Abstract excerpt

While the brain performs specialized functions across distinct regions, the spatial organization of the human brain proteome remains largely uncharted. Here we present a comprehensive spatially-resolved proteome atlas of the human brain, analyzing over two thousand MRI- guided locations across four individuals. Proteome analysis integrated with transcriptomics reveals extensive post-transcriptional regulation, wit...

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Identifiers and source

Literature Corpus work
e7843221-1715-5e40-9855-190e5c4f69e9
DOI
10.1101/2025.10.16.682772
Open publication

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A spatially-resolved human brain proteome atlas for understanding function and diseaseDOI 10.1101/2025.10.16.682772
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