Article
Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects.
Nucleic acids research - 1 Sept 2011
Keegan Liam P, McGurk Leeane, Palavicini Juan Pablo, Brindle James, Paro Simona, Li Xianghua, Rosenthal Joshua J C, O'Connell Mary A
Abstract excerpt
Flies with mutations in the single Drosophila Adar gene encoding an RNA editing enzyme involved in editing 4% of all transcripts have severe locomotion defects and develop age-dependent neurodegeneration. Vertebrates have two ADAR-editing enzymes that are catalytically active; ADAR1 and ADAR2. We show that human ADAR2 rescues Drosophila Adar mutant phenotypes. Neither the short nuclear ADAR1p110 isoform nor the...
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