Article

Recombination alters the receptor binding and furin cleavage site in novel bat-borne HKU5-CoV-2 coronavirus

2025-04-18

Abstract excerpt

HKU5-CoV-2 is a new bat-infecting coronavirus phylogenetically related to MERS-CoV. It has recently been confirmed that HKU5-CoV-2 can enter human cells and organoids in vitro via the ACE2 receptor, raising concerns about its pandemic potential due to zoonotic spillover. Whether recombination has an influence on HKU5-CoV-2 is completely unclear to date. Here we report the first evidence of HKU5-CoV-2 viral recomb...

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Literature Corpus work: 372c5994-ac16-5d42-8297-53124fde8fcc
DOI: 10.1101/2025.04.17.649446

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